The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2008
Filed:
Jul. 12, 2005
Jonathan S. Stamler, Chapel Hill, NC (US);
Joseph Bonaventura, Beaufort, NC (US);
John R. Pawloski, Raleigh, NC (US);
Timothy J. Mcmahon, Durham, NC (US);
Jonathan S. Stamler, Chapel Hill, NC (US);
Joseph Bonaventura, Beaufort, NC (US);
John R. Pawloski, Raleigh, NC (US);
Timothy J. McMahon, Durham, NC (US);
Duke University, Durham, NC (US);
Abstract
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NOgroups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal Ometabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal Odelivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.