The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2008
Filed:
Mar. 11, 2005
Shukuan LI, San Diego, CA (US);
Zhijian Yang, San Diego, CA (US);
Xinghua Sun, San Diego, CA (US);
Yuying Tan, San Diego, CA (US);
Shigeo Yagi, San Diego, CA (US);
Shukuan Li, San Diego, CA (US);
Zhijian Yang, San Diego, CA (US);
Xinghua Sun, San Diego, CA (US);
Yuying Tan, San Diego, CA (US);
Shigeo Yagi, San Diego, CA (US);
Anticancer, Inc., San Diego, CA (US);
Abstract
The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life.