The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2008
Filed:
Jan. 10, 2003
Tatsushi Toyokuni, Sherman Oaks, CA (US);
Nagichettiar Satyamurthy, Los Angeles, CA (US);
Harvey R. Herschman, Los Angeles, CA (US);
Michael E. Phelps, Encino, CA (US);
Jorge R. Barrio, Agoura Hills, CA (US);
Tatsushi Toyokuni, Sherman Oaks, CA (US);
Nagichettiar Satyamurthy, Los Angeles, CA (US);
Harvey R. Herschman, Los Angeles, CA (US);
Michael E. Phelps, Encino, CA (US);
Jorge R. Barrio, Agoura Hills, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.