The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2008
Filed:
Jun. 23, 2004
Stephen Howard Cypes, Santa Clara, CA (US);
Alex Minhua Chen, Metuchen, NJ (US);
Russell R. Ferlita, Westfield, NJ (US);
Karl Hansen, Atlantic Highlands, NJ (US);
Ivan Lee, Piscataway, NJ (US);
Vicky K. Vydra, Fair Lawn, NJ (US);
Robert M. Wenslow, Jr., East Windsor, NJ (US);
Stephen Howard Cypes, Santa Clara, CA (US);
Alex Minhua Chen, Metuchen, NJ (US);
Russell R. Ferlita, Westfield, NJ (US);
Karl Hansen, Atlantic Highlands, NJ (US);
Ivan Lee, Piscataway, NJ (US);
Vicky K. Vydra, Fair Lawn, NJ (US);
Robert M. Wenslow, Jr., East Windsor, NJ (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of diabetes, obesity, and high blood pressure.