The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2008
Filed:
Jan. 31, 2005
Saleem Ahmad, Wall, NJ (US);
Shung C. Wu, Princeton, NJ (US);
Steven V. O'neil, Newtown, PA (US);
Khehyong Ngu, Pennington, NJ (US);
Karnail S. Atwal, Newtown, PA (US);
David S. Weinstein, East Windsor, NJ (US);
Saleem Ahmad, Wall, NJ (US);
Shung C. Wu, Princeton, NJ (US);
Steven V. O'Neil, Newtown, PA (US);
Khehyong Ngu, Pennington, NJ (US);
Karnail S. Atwal, Newtown, PA (US);
David S. Weinstein, East Windsor, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—Rwherein Ris H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl group, R, R, Rand Rare as defined herein, and where X is N, Ris preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.