The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2008
Filed:
Dec. 12, 2005
Vladimir Naddaka, Lod, IL;
Shady Saeed, Haifa, IL;
Dionne Montviliski, Givataim, IL;
Lior Zelikovitch, Mazkeret Batia, IL;
Oded Arad, Rechovot, IL;
Joseph Kaspi, Givatayim, IL;
Vladimir Naddaka, Lod, IL;
Shady Saeed, Haifa, IL;
Dionne Montviliski, Givataim, IL;
Lior Zelikovitch, Mazkeret Batia, IL;
Oded Arad, Rechovot, IL;
Joseph Kaspi, Givatayim, IL;
Chemagis Ltd., Bnei-Brak, IL;
Abstract
The present invention provides a process for preparing 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (Imiquimod) of formula (I). The process comprises heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with formamide, and optionally with bubbling of gaseous ammonia to afford Imiquimod of formula (I). According to the present invention, by using this process and novel purification methods, essentially as described herein, highly pure Imiquimod is obtained.