Pyridine and pyrimidine derivatives

Abstract

Compounds of formula (1) are described in which Rand Ris each independently a hydrogen atom or a group R, or Rand Rtogether form an oxo (═O) or thio (═S) group; X is a N atom or an optionally substituted CH group: Y is a —O— or —S— atom or —SO— or —SO— group or an optionally substituted —CH— or —NH— group with the proviso that when Rand Rtogether form an oxo (═O) or thio (═S) group Y is an optionally substituted —CH— or —NH-group; Lis a covalent bond or a linker atom or group; p is zero or the integer 1; Alkis an optionally substituted Caliphatic or Cheteroaliphatic chain; n is zero the integer 1, 2 or 3 with the proviso that when n is zero Y is an optionally substituted —CH— group; Ar is an optionally substituted Caromatic or Cheteroaromatic group; m is zero or the integer 1, 2 or 3; q is zero or the integer 1 or 2; R, Rand Rare hydrogen atoms or the substituents described in the patent specification; and the salts, solvates, hydrates and N-oxides thereof. The compounds are potent and selective inhibitors of p38 kinase and are useful in the treatment of immune or inflammatory disorders.