The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2008
Filed:
Mar. 12, 2003
N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as hiv integrase inhibitors
Melissa Egbertson, Ambler, PA (US);
H. Marie Langford, Lansdale, PA (US);
Jeffrey Y. Melamed, Warminster, PA (US);
John S. Wai, Harleysville, PA (US);
Wei Han, West Chester, PA (US);
Debbie S. Perlow, East Greenville, PA (US);
Linghang Zhuang, Chalfont, PA (US);
Mark Embrey, North Wales, PA (US);
Melissa Egbertson, Ambler, PA (US);
H. Marie Langford, Lansdale, PA (US);
Jeffrey Y. Melamed, Warminster, PA (US);
John S. Wai, Harleysville, PA (US);
Wei Han, West Chester, PA (US);
Debbie S. Perlow, East Greenville, PA (US);
Linghang Zhuang, Chalfont, PA (US);
Mark Embrey, North Wales, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I): wherein R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.