The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2008
Filed:
Feb. 07, 2003
David B. Olsen, Lansdale, PA (US);
Robert L. Lafemina, Schwenksville, PA (US);
Anne B. Eldrup, Danbury, CT (US);
Sanjib Bera, Blacksburg, VA (US);
David B. Olsen, Lansdale, PA (US);
Robert L. LaFemina, Schwenksville, PA (US);
Anne B. Eldrup, Danbury, CT (US);
Sanjib Bera, Blacksburg, VA (US);
Merck & Co., Inc., Rahway, NJ (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/or for the treatment of vaccinia virus and variola virus infection. The nucleoside compounds may be administered alone or in combination with other agents active against orthopoxvirus infection, in particular against vaccinia virus or variola virus infection. Another aspect of the present invention provides for the use of such nucleoside compounds in the manufacture of a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection. Yet a further aspect of the present invention provides such nucleoside compounds for use as a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection.