The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2008
Filed:
Sep. 19, 2001
Gerald R. Crabtree, Woodside, CA (US);
Isabella Graef, Woodside, CA (US);
Feng Chen, Palo Alto, CA (US);
Gerald R. Crabtree, Woodside, CA (US);
Isabella Graef, Woodside, CA (US);
Feng Chen, Palo Alto, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
Methods and compositions for modulating angiogenesis in a host are provided. In the subject methods, an effective amount of Ca/calcineurin/NF-ATc signaling pathway modulatory agent is administered to the host. In many embodiments, the Ca/calcineurin/NF-ATc signaling pathway modulatory agent is an NF-ATc antagonist, e.g., in those embodiments of inhibiting angiogenesis. The subject methods find use in a variety of different applications, including the inhibition of tumor growth and the treatment of disease conditions characterized by tumor presence. Also provided are methods of screening for agents that inhibit angiogenesis by modulating the Ca/calcineurin/NF-ATc signaling pathway.