The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2008
Filed:
Jun. 27, 2002
Ann Marie Janson, Stockholm, SE;
Jonas Frisen, Stockholm, SE;
Clas Johansson, Stockholm, SE;
Stefan Momma, Spinga, SE;
Diana Clarke, Cambridge, MA (US);
Ming Zhao, Solna, SE;
Urban Lendahl, Stockholm, SE;
Kioumars Delfani, Solna, SE;
Ann Marie Janson, Stockholm, SE;
Jonas Frisen, Stockholm, SE;
Clas Johansson, Stockholm, SE;
Stefan Momma, Spinga, SE;
Diana Clarke, Cambridge, MA (US);
Ming Zhao, Solna, SE;
Urban Lendahl, Stockholm, SE;
Kioumars Delfani, Solna, SE;
NeuroNova AB, Stockholm, SE;
Abstract
The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis transmembrane conductance regulator), and which cell also comprises at least one cilium. The invention also relates to preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells, in vitro and in vivo assays based thereon and various other uses of the novel ependymal cells according to the invention.