The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2008
Filed:
Nov. 16, 2006
Yong Seo Cho, Seoul, KR;
Hyunah Choo, Seoul, KR;
AE Nim Pae, Seoul, KR;
Joo Hwan Cha, Seoul, KR;
Hun Yeong Koh, Seoul, KR;
Hwa-sil Kim, Seoul, KR;
Hyewhon Rhim, Seoul, KR;
Seon Hee Seo, Seoul, KR;
Yong Seo Cho, Seoul, KR;
Hyunah Choo, Seoul, KR;
Ae Nim Pae, Seoul, KR;
Joo Hwan Cha, Seoul, KR;
Hun Yeong Koh, Seoul, KR;
Hwa-Sil Kim, Seoul, KR;
Hyewhon Rhim, Seoul, KR;
Seon Hee Seo, Seoul, KR;
Korea Institute of Science and Technology, Seoul, KR;
Abstract
The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of Formula (1) show selective antagonistic activity against T-type calcium channel, thus being effective in treating brain diseases, cardiac diseases and neurogenic pains: wherein Ris a phenyl or a benzyl group, optionally substituted with a moiety selected from the group consisting of a halogen atom, a C-Calkoxy, a C-Calkyl, and a cyano group; Ris a heterocyclic group selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, and piperazinyl groups, wherein the heterocyclic group is optionally substituted with a C-Calkyl group; and n is 1 or 2.