The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2008
Filed:
Mar. 05, 2001
Riad Kharrat, El Manar I, TN;
Kamel Mabrouk, Les Pennes-Mirabeau, TN;
Mohammed El-ayeb, El Ouardia, TN;
Hervé Rochat, Mimet, FR;
Jean-marc Sabatier, Chateauneuf-le-Rouge, FR;
Riad Kharrat, El Manar I, TN;
Kamel Mabrouk, Les Pennes-Mirabeau, TN;
Mohammed El-Ayeb, El Ouardia, TN;
Hervé Rochat, Mimet, FR;
Jean-Marc Sabatier, Chateauneuf-le-Rouge, FR;
Cellpep Pharma Inc., Verdun, Quebec, CA;
Abstract
Maurocalcine, a novel toxin isolated from the venom of the Tunisian chactidae scorpion, has the amino acid sequence GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR (SEQ. ID. No. 1). It potently and reversibly modifies channel gating behaviour of type 1 ryanodine receptor (RyR1) by inducing prominent subconductance behavior. Maurocalcine and its bioactive structural analogues—preferably those containing the KKCKRR motif corresponding to part of the II-III loop of the alpha1S subunit of the voltage-dependent skeletal muscle calcium channel dihydropyridine receptor—appear to possess a therapeutic potential, notably as candidate immuno-suppressive drugs, and for the treatment of pathologies in humans that may involve a dysfunction of calcium channels.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile