The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2008
Filed:
Oct. 22, 1996
Andrew David Goodearl, Chorleywood, GB;
Paul Stroobant, London, GB;
Luisa Minghetti, Bagnacavallo, IT;
Michael Waterfield, Newbury, GB;
Mark Marchionni, Arlington, MA (US);
Maio Su Chen, Arlington, MA (US);
Ian Hiles, London, GB;
Andrew David Goodearl, Chorleywood, GB;
Paul Stroobant, London, GB;
Luisa Minghetti, Bagnacavallo, IT;
Michael Waterfield, Newbury, GB;
Mark Marchionni, Arlington, MA (US);
Maio Su Chen, Arlington, MA (US);
Ian Hiles, London, GB;
Acorda Therapeutics, Inc., Hawthorne, NY (US);
Ludwig Institute for Cancer Research, New York, NY (US);
Abstract
Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Also included is the mature GGF peptide and the DNA encoding said peptide, exclusive of the N-terminal signal sequence. The mature GGF peptide and DNA encoding the same are also useful for treatment of conditions of the central nervous system. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells.