The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2008
Filed:
Sep. 05, 2003
Joel W. Schwartz, Nashville, TN (US);
Randy D. Blakely, Brentwood, TN (US);
Louis Defelice, Nashville, TN (US);
Joel W. Schwartz, Nashville, TN (US);
Randy D. Blakely, Brentwood, TN (US);
Louis DeFelice, Nashville, TN (US);
Vanderbilt University, Nashville, TN (US);
Abstract
The invention describes the finding that 4-(4-dimethylaminostyrl)-N-methylpyridinium or ASPis a fluorescent substrate that is transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using ASP. The invention also provides rapid methods for screening for modulators of neurotransmitter transport. As neurotransmitter transporter defects are associated with numerous neurological disorders, the invention also provides methods for treating neurotransmitter transport-associated defects/conditions using the modulators identified by the screening methods of the invention.