The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2008
Filed:
Dec. 09, 2003
William F. Weitzel, Ypsilanti, MI (US);
Kang Kim, Ann Arbor, MI (US);
Matthew O'donnell, Ann Arbor, MI (US);
Jonathan M. Rubin, Scio Township, MI (US);
Hua Xie, Ann Arbor, MI (US);
Xunchang Chen, Ann Arbor, MI (US);
William F. Weitzel, Ypsilanti, MI (US);
Kang Kim, Ann Arbor, MI (US);
Matthew O'Donnell, Ann Arbor, MI (US);
Jonathan M. Rubin, Scio Township, MI (US);
Hua Xie, Ann Arbor, MI (US);
Xunchang Chen, Ann Arbor, MI (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
Methods and systems for measuring mechanical property of a vascular wall and a method and system for determining health of a vascular structure are provided wherein local deformation of a vessel wall resulting from physiologic pressures with altered transmural forces is measured. A non-invasive free-hand ultrasound scanning-procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. When the applied pressure matched the internal baseline diastolic pressure, strain and strain rate increased by a factor of 10 over a cardiac cycle. Radial arterial strain was assessed in the vessel wall over the entire deformation procedure using a phase-sensitive, two-dimensional speckle-tracking algorithm. An elastic modulus reconstruction procedure was developed to estimate the non-linear elastic properties of the vascular wall.