The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2008
Filed:
Sep. 19, 2005
Ronald T. Raines, Madison, WI (US);
Laura L. Kiessling, Madison, WI (US);
Bradley L. Nilsson, Madison, WI (US);
Yi He, Madison, WI (US);
Matthew B. Soellner, Madison, WI (US);
Ronald J. Hinklin, Longmont, CO (US);
Ronald T. Raines, Madison, WI (US);
Laura L. Kiessling, Madison, WI (US);
Bradley L. Nilsson, Madison, WI (US);
Yi He, Madison, WI (US);
Matthew B. Soellner, Madison, WI (US);
Ronald J. Hinklin, Longmont, CO (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.