The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2008
Filed:
Nov. 08, 2002
Bart Petrus Anna Maria Jozef Medaer, Lille, BE;
Sigrid Carl Maria Stokbroekx, Beerse, BE;
Yves Georges Ruysschaert, Vosselaar, BE;
Joannes Josephus Maria Willems, Oud-Turnhout, BE;
Johan Erwin Edmond Weerts, Beerse, BE;
Bart Petrus Anna Maria Jozef Medaer, Lille, BE;
Sigrid Carl Maria Stokbroekx, Beerse, BE;
Yves Georges Ruysschaert, Vosselaar, BE;
Joannes Josephus Maria Willems, Oud-Turnhout, BE;
Johan Erwin Edmond Weerts, Beerse, BE;
Janssen Pharmaceutica, N.V., , BE;
Abstract
The object of the present invention is a novel mandelate salt of a substituted tetracyclic tetrahydrofuran derivative according to Formula (I) the N-oxide forms and the stereochemically isomeric forms thereof, wherein Rand Reach independently are hydrogen or Calkyl and Rand Reach independently are hydrogen or halogen. In the foregoing definitions Calkyl defines straight and branched saturated hydrocarbon radicals having from 1 to 6 carbon atoms such as, for example, methyl, ethyl, propyl, butyl, 1-methylpropyl, 1,1-dimethylethyl, pentyl or hexyl. The novel mandelate salt is not light-sensitive and is far more stable than the prior art salts at room temperature, enhanced temperature and at relative high humidities and in aqueous media. Also disclosed are pharmaceutical compositions comprising mandelate salts according to the invention, mandelate salts according to the invention for use as a medicine, a process for preparing the mandelate salts according to the invention and the use of the mandelate salts and pharmaceutical compositions comprising mandelate salts according to the invention for the treatment or the prevention of CNS disorders, cardiovascular disorders and gastrointestinal disorders.