The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2008
Filed:
Sep. 17, 2001
Sierd Bron, Haren, NL;
Jan D. H. Jongbloed, Groningen, NL;
Joerg Muller, Jena, DE;
Jan M. Van Dijl, Harkstede, NL;
Sierd Bron, Haren, NL;
Jan D. H. Jongbloed, Groningen, NL;
Joerg Muller, Jena, DE;
Jan M. Van Dijl, Harkstede, NL;
Genencor International, Inc., Palo Alto, CA (US);
Abstract
Described herein are methods to enhance protein secretion in a host cell. In preferred embodiment, the host cell is a gram-positive microorganism such as a. In another preferred embodiment, the host cell is a gram-negative microorganism. Preferably the gram-negative microorganism is anor a member of the genus. Protein secretion may be enhanced by the overexpression of protein components of the Tat pathway. Alternatively, secretion of foreign proteins can be selectively enhanced by forming a chimeric polypeptide comprising a tat signal sequence and the protein of interest. In a preferred embodiment, the tat signal sequence is selected from phoD or LipA.