The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2008
Filed:
Oct. 15, 2003
Michael G. Kornacker, Princeton, NJ (US);
Robert A. Copeland, Hockessin, DE (US);
Joseph Hendrick, Portland, CT (US);
Zhihong Lai, West Chester, PA (US);
Claudio Mapelli, Plainsboro, NJ (US);
Mark Richard Witmer, Pennington, NJ (US);
Jovita Marcinkeviciene, Washington Crossing, PA (US);
William Metzler, Doylestown, PA (US);
Ving Lee, Hamilton, NJ (US);
Douglas James Riexinger, Flemington, NJ (US);
Michael G. Kornacker, Princeton, NJ (US);
Robert A. Copeland, Hockessin, DE (US);
Joseph Hendrick, Portland, CT (US);
Zhihong Lai, West Chester, PA (US);
Claudio Mapelli, Plainsboro, NJ (US);
Mark Richard Witmer, Pennington, NJ (US);
Jovita Marcinkeviciene, Washington Crossing, PA (US);
William Metzler, Doylestown, PA (US);
Ving Lee, Hamilton, NJ (US);
Douglas James Riexinger, Flemington, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.