The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 25, 2007

Filed:

Dec. 06, 2002
Applicants:

Ruth Tenbrink, Kalamazoo, MI (US);

Michel Maillard, Redwood Shores, CA (US);

Martha Warpehoski, Portage, MI (US);

Inventors:

Ruth TenBrink, Kalamazoo, MI (US);

Michel Maillard, Redwood Shores, CA (US);

Martha Warpehoski, Portage, MI (US);

Assignees:

Elan Pharmaceuticals, Inc., So. San Francisco, CA (US);

Pharmacia & Upjohn Company, Kalamazoo, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 233/65 (2006.01); A61K 31/165 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, R, and Rare defined herein. These compounds interact with and inhibit the activity of the enzyme beta-secretase. These compounds are therefore useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions and methods of treatment of these diseases are also disclosed.


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