The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2007
Filed:
Dec. 03, 2004
Narendra Joshi, Navi Mumbai, IN;
Shekhar Bhaskar Bhirud, Navi Mumbai, IN;
Batchu Chandrasekhar, Navi Mumbai, IN;
K. Eswara Rao, Navi Mumbai, IN;
Subhash Damle, Thane Dist., IN;
Narendra Joshi, Navi Mumbai, IN;
Shekhar Bhaskar Bhirud, Navi Mumbai, IN;
Batchu Chandrasekhar, Navi Mumbai, IN;
K. Eswara Rao, Navi Mumbai, IN;
Subhash Damle, Thane Dist., IN;
Glenmark Pharmaceuticals Limited, Mumbai, IN;
Abstract
An improved process for the preparation of pyrimidine derivatives is provided comprising reacting a Wittig reagent of the general formula wherein R is an alkyl of from 1 to 10 carbon atoms, aryl or arylalkyl, Ris a substituted or unsubstituted hydrocarbon group, Rand Rare the same or different and are hydrogen or a substituted or unsubstituted hydrocarbon group; Z is sulfur, oxygen, sulfonyl, or imino which may be substituted by formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, amino substituted by sulfonyl or alkylsulfonyl, and sulfonyl substituted by alkyl, amino or alkylamino and X is a halogen; with an aldehyde of the general formula wherein Ris hydrogen, a lower alkyl or a cation capable of forming a non-toxic pharmaceutically acceptable salt and each Rare the same or different and are hydrogen or a hydrolyzable protecting group, or each R, together with the oxygen atom to which each is bonded, form a hydrolyzable cyclic protecting group, or each Ris bonded to the same substituent which is bonded to each oxygen atom to form a hydrolyzable protecting group; in the presence of a base.