The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2007
Filed:
Oct. 02, 2002
Naoya Kobayashi, Okayama-shi, Okayama, JP;
Noriaki Tanaka, Asakuchi-gun, Okayama, JP;
Teru Okitsu, Okayama-shi, Okayama, JP;
Ji-won Yoon, Calgary, Alberta, CA;
Hee-sook Jun, Calgary, Alberta, CA;
Seungjin Shin, Calgary, Alberta, CA;
Naoya Kobayashi, Okayama-shi, Okayama, JP;
Noriaki Tanaka, Asakuchi-gun, Okayama, JP;
Teru Okitsu, Okayama-shi, Okayama, JP;
Ji-Won Yoon, Calgary, Alberta, CA;
Hee-Sook Jun, Calgary, Alberta, CA;
Seungjin Shin, Calgary, Alberta, CA;
Other;
Abstract
The present invention provides a cell line which can be substituted for β cells in human mature pancreatic islets and express insulin in a glucose-concentration dependent manner, and enables the easy obtainment of the number of cells which meets the demand. The present invention also provides a therapeutical cell preparation for treating diabetes. The cell lines of the present invention can be obtained by integrating both a nucleotide sequence encoding tamoxifen-induced Cre recombinase and a nucleotide sequence encoding insulin regulated by glucose-sensitive promoter into the chromosome in a human immortalized hepatic cell line FERM BP-7498 containing the TERT gene inserted in between a pair of LoxP sequences.