The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2007
Filed:
Feb. 25, 2004
Vicki I. Chin, La Jolla, CA (US);
Sangeeta N. Bhatia, La Jolla, CA (US);
Michael J. Sailor, La Jolla, CA (US);
Boyce E. Collins, La Jolla, CA (US);
Vicki I. Chin, La Jolla, CA (US);
Sangeeta N. Bhatia, La Jolla, CA (US);
Michael J. Sailor, La Jolla, CA (US);
Boyce E. Collins, La Jolla, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients by means such as perfusion of the nanoporous silicon support with fluid. The macropores may be between 0.2 and 200 microns and be coated with a substance that promotes cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The supports are sufficiently robust that they may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.