The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2007
Filed:
Sep. 10, 2003
Carl T. Wild, Gaithersburg, MD (US);
Carol D. Weiss, Bethesda, MD (US);
Carl T. Wild, Gaithersburg, MD (US);
Carol D. Weiss, Bethesda, MD (US);
The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Panacos Pharmaceuticals, Inc., Gaitherburg, MD (US);
Abstract
The present invention is directed to the induction and characterization of a humoral immune response targeting 'entry-relevant' gp41 structures. In its broadest aspect, the present invention is directed to methods of raising a neutralizing antibody response to a broad spectrum of HIV strains and isolates. The present invention targets particular molecular conformations or structures that occur at the cell surface of HIV during viral entry into host cells. Such a humoral response can be generated in vivo as a prophylactic measure in individuals to reduce or inhibit the ability of HIV to infect uninfected cells in the individual's body. Such a response can also be employed to raise antibodies against 'entry relevant' gp41 structures. These antibodies can be employed for therapeutic uses, and as tools for further illuminating the mechanism of HIV cell entry.