The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2007
Filed:
Jun. 13, 2003
Peter S. Linsley, Seattle, WA (US);
Jeffrey A. Ledbetter, Seattle, WA (US);
Nitin K. Damle, Monmount Junction, NJ (US);
William Brady, Bothell, WA (US);
Peter S. Linsley, Seattle, WA (US);
Jeffrey A. Ledbetter, Seattle, WA (US);
Nitin K. Damle, Monmount Junction, NJ (US);
William Brady, Bothell, WA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.