The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2007
Filed:
Apr. 14, 2004
Narendra Bam, King of Prussia, PA (US);
Jacob Bongers, King of Prussia, PA (US);
Robert B. Kirkpatrick, King of Prussia, PA (US);
Cheryl A. Janson, Hinsdale, IL (US);
Zdenka Jonak, King of Prussia, PA (US);
Xianyang Qiu, Mystic, CT (US);
Ping Yeh, King of Prussia, PA (US);
Kyung Johanson, King of Prussia, PA (US);
Narendra Bam, King of Prussia, PA (US);
Jacob Bongers, King of Prussia, PA (US);
Robert B. Kirkpatrick, King of Prussia, PA (US);
Cheryl A. Janson, Hinsdale, IL (US);
Zdenka Jonak, King of Prussia, PA (US);
Xianyang Qiu, Mystic, CT (US);
Ping Yeh, King of Prussia, PA (US);
Kyung Johanson, King of Prussia, PA (US);
SmithKline Beecham Corporation, Philadelphia, PA (US);
Abstract
Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.