The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2007
Filed:
Feb. 22, 2002
Applicants:
Lisa Mcconlogue, Burlingame, CA (US);
Mark E. Gurney, Reykjavik, IS;
Inventors:
Lisa McConlogue, Burlingame, CA (US);
Mark E. Gurney, Reykjavik, IS;
Assignees:
Elan Pharmaceuticals, Inc, South San Francisco, CA (US);
Pharmacia & Upjohn Company, Kalamazoo, MI (US);
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); A01K 67/033 (2006.01); G01N 33/00 (2006.01); C12N 15/00 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for development and hence is an appropriate therapeutic target. The transgenic animals are useful in various screening assays including identifying inhibitors of other enzymes involved in processing of APP to Aβ and determining a toxicity profile of inhibitors of BACE-1.