The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2007
Filed:
May. 25, 2001
Kensuke Egashira, Fukuoka, JP;
Yoshikazu Yonemitsu, Fukuoka, JP;
Katsuo Sueishi, Fukuoka, JP;
Yasuhiro Ikeda, Fukuoka, JP;
Yoshiyuki Inada, Kawanishi, JP;
Kensuke Egashira, Fukuoka, JP;
Yoshikazu Yonemitsu, Fukuoka, JP;
Katsuo Sueishi, Fukuoka, JP;
Yasuhiro Ikeda, Fukuoka, JP;
Yoshiyuki Inada, Kawanishi, JP;
Kensuke Egashira, Fukuoka, JP;
Takeda Chemical Industries Ltd., Osaka, JP;
Abstract
The present invention provides a prophylactic and/or therapeutic agent for pulmonary hypertension, comprising an antagonistic mutein of MCP-1 or a salt thereof, a DNA molecule comprising a nucleotide sequence encoding the antagonistic mutein of MCP-1, or a neutralizing antibody against MCP-1. The antagonistic mutein of MCP-1 or a salt thereof, the DNA molecule having a nucleotide sequence encoding the antagonistic mutein of MCP-1, or the neutralizing antibody against MCP-1 has hypotensive activity, and thus is useful as a pharmaceutical agent for preventing and/or treating pulmonary hypertension (primary pulmonary hypertension, in particular).