The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2007
Filed:
Nov. 26, 2004
Applicants:
Arieh Gertler, Rehovot, IL;
Isabelle Callebaut, Favières, FR;
Jean Djiane, Verrières le Buisson, FR;
Inventors:
Arieh Gertler, Rehovot, IL;
Isabelle Callebaut, Favières, FR;
Jean Djiane, Verrières le Buisson, FR;
Assignees:
Yissum Research and Development Company of the Hebrew University of Jerusalem, Jerusalem, FR;
Universités Paris 6 et Paris 7, Paris, FR;
Institut Nationale de la Recherche Agronomique (INRA), Paris, FR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions-of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, and fragments of said leptin antagonists.