The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2007
Filed:
Nov. 09, 2001
Samuel James Dominianni, Indianapolis, IN (US);
Garret Jay Etgen, Carmel, IN (US);
Richard Duane Johnston, Greenfield, IN (US);
Nathan Bryan Mantlo, Brownsburg, IN (US);
Daniel Ray Mayhugh, Carmel, IN (US);
Ashraf Saeed, Carmel, IN (US);
Richard Craig Thompson, Frankfort, IN (US);
Xiaodong Wang, Carmel, IN (US);
Christopher Randall Schmid, Indianapolis, IN (US);
Yanping Xu, Fishers, IN (US);
Samuel James Dominianni, Indianapolis, IN (US);
Garret Jay Etgen, Carmel, IN (US);
Richard Duane Johnston, Greenfield, IN (US);
Nathan Bryan Mantlo, Brownsburg, IN (US);
Daniel Ray Mayhugh, Carmel, IN (US);
Ashraf Saeed, Carmel, IN (US);
Richard Craig Thompson, Frankfort, IN (US);
Xiaodong Wang, Carmel, IN (US);
Christopher Randall Schmid, Indianapolis, IN (US);
Yanping Xu, Fishers, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C-Calkyl, aryl-C-alkyl, heteroaryl-C-alkyl, C-Ccycloalkylaryl-C-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C-Calkyl, C-Ccycloalkyl and heteroaryl. X is a C-Calkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH)COOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C-Calkyl, C-Calkoxy. Additionally, R4 is H, halo, a substituted or unsubstituted group selected from C-Calkyl, C-Calkoxy, C-Ccycloalkyl, arylC-Calkyl and phenyl, or R3 and R4 are combined to form a C-Ccycloalkyl.