The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2007
Filed:
Dec. 14, 2000
Frans Eduard Janssens, Beerse, BE;
Jérôme Emile Georges Guillemont, Issy-les-Moulineaux, FR;
François Maria Sommen, Beerse, BE;
Frans Eduard Janssens, Beerse, BE;
Jérôme Emile Georges Guillemont, Issy-les-Moulineaux, FR;
François Maria Sommen, Beerse, BE;
Janssen Pharmaceuitca N.V., , BE;
Abstract
The present invention relates to compounds of formula (I) their prodrugs, N-oxides, addition salts, quaternary amines and stereochemically isomeric forms, wherein the bivalent radical -{circle around (A)}- represents a saturated or an unsaturated homopiperidinyl having one double bond, and wherein said bivalent radical -{circle around (A)}- is substituted with Rbeing hydrogen, hydroxy, Calkyl, or Calkyloxy; -a=a-a=a- represents an optionally substituted bivalent radical; Ris hydrogen, Calkyl, aryl, Calkyl substituted with aryl, Calkyloxycarbonyl, arylcarbonyl, arylCalkylarbonyl Calkylcarbonyl, trifluoromethyl, trifluoromethylcarbonyl, Calkylsulfonyl, arylsulfonyl, methanesulfonyl, benzenesulfonyl, trifluoromethanesulfonyl, dimethylsulfamoyl; X represents O, S or NR, wherein Ris hydrogen, Calkyl, methanesulfonyl, benzenesulfonyl, trifluoromethanesulfonyl, dimethylsulfamoyl, Calkyl substituted with aryland optionally with hydroxy, CalkylcarbonylCalkyl substituted with aryl; arylis optionally substituted phenyl, optionally substituted pyridinyl, naphthyl, quinolinyl, or 1,3-benzodioxolyl; arylis optionally substituted phenyl; fundic relaxating activity. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating dyspeptic symptoms, irritable bowel syndrome and other conditions related to a hampered or impaired relaxation of the fundus.