The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2007
Filed:
Mar. 08, 2002
Hans-georg Lerchen, Leverkusen, DE;
Jörg Baumgarten, Wuppertal, DE;
Andreas Schoop, Mittelbiberach, DE;
Markus Albers, Leverkusen, DE;
Hans-Georg Lerchen, Leverkusen, DE;
Jörg Baumgarten, Wuppertal, DE;
Andreas Schoop, Mittelbiberach, DE;
Markus Albers, Leverkusen, DE;
Bayer Akiengesellschaft, Leverkusen, DE;
Abstract
The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to αβintegrin antagonists via preferred linking units which can be selectively cleaved by elastase, i.e. by an enzyme which can especially be found in tumor tissue. The preferred linking units provide sufficient stability of the conjugate of cytostatic and αβintegrin antagonist in biological fluids and, at the same time, the desired intracellular action within tumor cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic.