The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2007
Filed:
Nov. 20, 2002
Kevin J. Tracey, Old Greenwich, CT (US);
Huan Yang, Douglaston, NY (US);
Howland Shaw Warren, Jr., Cambridge, MA (US);
Mitchell P. Fink, Pittsburgh, PA (US);
Kevin J. Tracey, Old Greenwich, CT (US);
Huan Yang, Douglaston, NY (US);
Howland Shaw Warren, Jr., Cambridge, MA (US);
Mitchell P. Fink, Pittsburgh, PA (US);
The Feinstein Institute for Medical Research, Manhasset, NY (US);
The General Hospital Corporation, Boston, MA (US);
University of Pittsburgh-Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.