The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2007
Filed:
Apr. 24, 2006
Lushi Tan, Edison, NJ (US);
Benjamin T. Dorner, Hoboken, NJ (US);
Wenjie LI, Edison, NJ (US);
Nobuyoshi Yasuda, Mountainside, NJ (US);
Frederick W. Hartner, Somerville, NJ (US);
Lushi Tan, Edison, NJ (US);
Benjamin T. Dorner, Hoboken, NJ (US);
Wenjie Li, Edison, NJ (US);
Nobuyoshi Yasuda, Mountainside, NJ (US);
Frederick W. Hartner, Somerville, NJ (US);
Merck & Co., Inc, Rahway, NJ (US);
Abstract
The present invention relates to synthetic processes useful in the preparation of fluorinated 4-azasteroid derivatives that modulate androgen receptors and have application in the treatment of conditions caused by androgen deficiency or androgen receptor hyperactivity, such as osteoporosis, periodontal disease, bone fracture, frailty, erectile dysfunction, loss of libido, androgen-dependent cancers and sarcopenia. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.