The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2007
Filed:
Dec. 28, 2000
Darcy Madden, Legal Representative, San Diego, CA (US);
David Paul Weiner, Del Mar, CA (US);
Jennifer Ann Chaplin, San Diego, CA (US);
Dan E. Robertson, San Diego, CA (US);
Darcy Madden, legal representative, San Diego, CA (US);
David Paul Weiner, Del Mar, CA (US);
Jennifer Ann Chaplin, San Diego, CA (US);
Dan E. Robertson, San Diego, CA (US);
Verenium Corporation, San Diego, CA (US);
Abstract
In accordance with the present invention there are provided methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide and ammonia or an anmionium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the enantiomerically pure α-substituted carboxylic acid, such as, for example, α-amino acids and α-hydroxy acids.