The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2007
Filed:
Jun. 13, 2003
Applicants:
Christiane Ferran, West Roxbury, MA (US);
Maria B. Arvelo, Quincy, MA (US);
Inventors:
Christiane Ferran, West Roxbury, MA (US);
Maria B. Arvelo, Quincy, MA (US);
Assignee:
Beth Israel Deaconess Medical Center, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61N 31/70 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention features a novel method of treating vascular disease that involves modifying smooth muscle cells to express a gene encoding a protein having both anti-inflammatory and pro-apoptotic activity. Preferably, the protein of the invention also has an anti-proliferative effect in smooth muscle cells. In general, the method is useful in preparing vascularized organs and vessels for transplant into a patient. Alternatively, the present invention can be applied to treat atherosclerotic lesions in damaged vessels.