The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2007
Filed:
Apr. 10, 2002
Adelbert Bacher, 85748 Garching, DE;
Felix Rohdich, 85406 Zolling, DE;
Petra Adam, Kramsach, AT;
Sabine Amslinger, Weiden, DE;
Wolfgang Eisenreich, Freising, DE;
Stefan Hecht, Bad Aibling, DE;
Adelbert Bacher, 85748 Garching, DE;
Felix Rohdich, 85406 Zolling, DE;
Petra Adam, Kramsach, AT;
Sabine Amslinger, Weiden, DE;
Wolfgang Eisenreich, Freising, DE;
Stefan Hecht, Bad Aibling, DE;
Other;
Abstract
The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.