The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2007
Filed:
Oct. 10, 2003
Yuji Hayashi, Nagoya, JP;
Mitsuhiro Makino, Nagoya, JP;
Toshiyuki Kouzaki, Nagoya, JP;
Motohiro Takeda, Nagoya, JP;
Takahito Jomori, Nagoya, JP;
Yuji Hayashi, Nagoya, JP;
Mitsuhiro Makino, Nagoya, JP;
Toshiyuki Kouzaki, Nagoya, JP;
Motohiro Takeda, Nagoya, JP;
Takahito Jomori, Nagoya, JP;
Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya-Shi, JP;
Abstract
A GLP-1 derivative is provided including an amino acid sequence of GLP-1 (7-35) having deletion, substitution and/or addition of one or more amino acids and having Waa-(Xaa)n-Yaa (in which Waa is Arg or Lys, Xaa is Arg or Lys, n is an integer of 0 to 14, and Yaa is Arg, Arg-NH, Lys, Lys-NHor Hse) added to the C-terminus of the peptide having a GLP-1 activity. These derivatives are highly absorbable via a mucous membrane. The GLP-1 derivative can be conferred with resistance to dipeptidyl peptidase IV by substituting amino acid 8 in its GLP-1 amino acid sequence with Ser, or with resistance to trypsin by substituting amino acids 26 and 34 with Gln and Asn, respectively. The absorption efficiency of the GLP-1 derivatives via mucous membranes can be further improved by preparing a composition using a charge-regulated fat emulsion regulated to be negatively charged thereon.