The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2007
Filed:
Jul. 09, 2004
Wolfgang Goehring, Steinen, DE;
Peter John Harrington, Louisville, CO (US);
Lewis M Hodges, Longmont, CO (US);
David a Johnston, Louisville, CO (US);
Goesta Rimmler, Bad Krozingen, DE;
Wolfgang Goehring, Steinen, DE;
Peter John Harrington, Louisville, CO (US);
Lewis M Hodges, Longmont, CO (US);
David A Johnston, Louisville, CO (US);
Goesta Rimmler, Bad Krozingen, DE;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention relates to a process for the manufacture of compounds of formula wherein the substituents are as described hereinwhich comprises the steps of with a compound of formula to form a compound of formula b) converting the OH/═O function of compounds of formula XIV/XIVa into a leaving group P with a reagent containing a leaving group, selected from POCl, PBr, MeI and (FCSO)O to form a compound of formula wherein P is halogen or trifluoromethanesulfonate; and The compounds of formula I are valuable intermediates for the manufacture of therapeutically active compounds which have NK-1 antagonist activity.