The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2007
Filed:
Jun. 21, 2001
Guy W Bemis, Arlington, MA (US);
Julian M C. Golec, Swindon, GB;
David J Lauffer, Stow, MA (US);
Michael D Mullican, Needham, MA (US);
Mark a Murcko, Holliston, MA (US);
David J Livingston, Newtonville, MA (US);
Guy W Bemis, Arlington, MA (US);
Julian M C. Golec, Swindon, GB;
David J Lauffer, Stow, MA (US);
Michael D Mullican, Needham, MA (US);
Mark A Murcko, Holliston, MA (US);
David J Livingston, Newtonville, MA (US);
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Abstract
The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.