The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2007
Filed:
Jul. 26, 2005
Jon Hangeland, Morrisville, PA (US);
Minsheng Zhang, Warren, NJ (US);
Yolanda Caringal, Lawrenceville, NJ (US);
Denis Ryono, Princeton, NJ (US);
Yi-lin LI, Huddinge, SE;
Johan Malm, Skogas, SE;
YE Liu, Tullinge, SE;
Neeraj Garg, Tumba, SE;
Chris Litten, Tumba, SE;
Ana Maria Garcia Collazo, Stockholm, SE;
Konrad Koehler, Huddinge, SE;
Jon Hangeland, Morrisville, PA (US);
Minsheng Zhang, Warren, NJ (US);
Yolanda Caringal, Lawrenceville, NJ (US);
Denis Ryono, Princeton, NJ (US);
Yi-Lin Li, Huddinge, SE;
Johan Malm, Skogas, SE;
Ye Liu, Tullinge, SE;
Neeraj Garg, Tumba, SE;
Chris Litten, Tumba, SE;
Ana Maria Garcia Collazo, Stockholm, SE;
Konrad Koehler, Huddinge, SE;
Karo Bio AB, Huddinge, SE;
Abstract
New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; Ris halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; Rand Rare the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, at least one of Rand Rbeing other than hydrogen; Ris a carboxylic acid amide (CONR'R″) or an acylsulphonamide (CONHSOR′) derivative, or a pharmaceutically acceptable salt thereof, and all stereolsom thereof; or when n is equal to or greater than one, Rmay be heteroaromatic moiety which may be substituted or unsubstituted, or an amine (NR′R″). Ris hydrogen or an acyl (such as acetyl or benzoyl) or other group capable of bioconversion to generate the free phenol structure (wherein R—H). In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependant upon the expression of a Tregulated gene, wherein a compound as described above is administered in a therapeutically effective amount. Examples of such diseases associated with metabolism dysfunction or are dependent upon the expression of a Tregulated gene include obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmias, depression, osteoporosis, hypothyroidism, goiter, thyroid cancer as well as glaucoma, congestive heart failure and skin disorders.