The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2007
Filed:
May. 19, 1995
Richard D. Garman, Arlington, MA (US);
Julia L. Greenstein, West Newton, MA (US);
Mei-chang Kuo, Winchester, MA (US);
Bruce L. Rogers, Belmont, MA (US);
Henry M. Franzen, Watertown, MA (US);
Xian Chen, North Chelmsford, MA (US);
Sean Evans, Acton, MA (US);
Ze'ev Shaked, Berkeley, CA (US);
Richard D. Garman, Arlington, MA (US);
Julia L. Greenstein, West Newton, MA (US);
Mei-chang Kuo, Winchester, MA (US);
Bruce L. Rogers, Belmont, MA (US);
Henry M. Franzen, Watertown, MA (US);
Xian Chen, North Chelmsford, MA (US);
Sean Evans, Acton, MA (US);
Ze'ev Shaked, Berkeley, CA (US);
Merck Patent GmbH, Darmstadt, DE;
Abstract
The present invention provides isolated peptides of the major protein allergens of the genus. Peptides within the scope of the invention comprises at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.