The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2007
Filed:
Dec. 19, 2003
Peter Orth, New York City, NY (US);
Paul Reichert, Montville, NJ (US);
Vincent S. Madison, Mountain Lakes, NJ (US);
Wenyan Wang, Edison, NJ (US);
Jun Zou, Cranbury, NJ (US);
Peter Orth, New York City, NY (US);
Paul Reichert, Montville, NJ (US);
Vincent S. Madison, Mountain Lakes, NJ (US);
Wenyan Wang, Edison, NJ (US);
Jun Zou, Cranbury, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
The present invention discloses purified polypeptides that comprise an active human ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human ADAM33 catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human ADAM33. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human ADAM33 in structure based drug design to identify compounds that can modulate the enzymatic activity of human ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the human ADAMS33 catalytic domain.