The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2007
Filed:
Sep. 07, 2000
Naoki Midoh, Odawara, JP;
Kaoru Okakura, Odawara, JP;
Koichi Miyamoto, Odawara, JP;
Manabu Watanabe, Odawara, JP;
Koji Yanai, Odawara, JP;
Tetsuya Yasutake, Odawara, JP;
Sato Aihara, Odawara, JP;
Takafumi Futamura, Odawara, JP;
Horst Kleinkauf, Berlin, DE;
Takeshi Murakami, Odawara, JP;
Naoki Midoh, Odawara, JP;
Kaoru Okakura, Odawara, JP;
Koichi Miyamoto, Odawara, JP;
Manabu Watanabe, Odawara, JP;
Koji Yanai, Odawara, JP;
Tetsuya Yasutake, Odawara, JP;
Sato Aihara, Odawara, JP;
Takafumi Futamura, Odawara, JP;
Horst Kleinkauf, Berlin, DE;
Takeshi Murakami, Odawara, JP;
Meiji Seika Kaisha, Ltd., Tokyo-To, JP;
Abstract
The present invention provides an enzyme that synthesizes a cyclic depsipeptide, particularly the substance 1022, and a gene thereof. A cyclic depsipeptide synthetase according to the present invention comprises (a) an amino acid sequence of SEQ ID NO: 2 or (b) a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that have one or more modifications selected from a substitution, a deletion, an addition and an insertion and has cyclic depsipeptide synthetase activity. A cyclic depsipeptide synthetase gene according to the present invention comprises a nucleotide sequence encoding a cyclic depsipeptide synthetase. The present invention also provides a recombinant vector and a transformant for expressing the cyclic depsipeptide synthetase, and a mass production system for the cyclic depsipeptide. The present invention further provides a method for producing the cyclic depsipeptide synthetase.