The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2007
Filed:
Jun. 05, 2002
Bruce A. Green, New City, NY (US);
Randall K. Holmes, Golden, CO (US);
Michael G. Jobling, Aurora, CO (US);
Duzhang Zhu, Pomona, NY (US);
Bruce A. Green, New City, NY (US);
Randall K. Holmes, Golden, CO (US);
Michael G. Jobling, Aurora, CO (US);
Duzhang Zhu, Pomona, NY (US);
Wyeth Holdings Corporation, Madison, NJ (US);
The Regents of the University of Colorado, A Body Corporate, Aurora, CO (US);
Abstract
Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.