The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2007
Filed:
Aug. 23, 2001
Toshiyuki Takai, Sendai, JP;
Masao Ono, Sendai, JP;
Takae Yuasa, Osakasayama, JP;
Takeshi Watanabe, Saga, JP;
Toshiyuki Takai, Sendai, JP;
Masao Ono, Sendai, JP;
Takae Yuasa, Osakasayama, JP;
Takeshi Watanabe, Saga, JP;
Japan Science and Technology Agency, Kawaguchi-shi, Saitama, JP;
Abstract
The present invention provides an experimental model animal which does not develop anaphylaxis, a type I allergy, can specifically induce Arthus reaction, a type III allergy, is not affected by type I allergy and evaluates type III allergy inflammation individually, and a method of screening a reaction accelerating or inhibitory substance in a type III allergy reaction through FcγRIII by using said experimental model animal. In order to eliminate FcγRIIB that demonstrates suppressive action to response through FrγRIII, a mouse wherein the deletion mutation of both molecules of Lyn and FcγRIIB are homozygotic (LynIIB) was generated by mating Lyn knockout mouse (Lyn) and FcγRIIB knockout mouse (FcγRIIB), and was used to measure and evaluate the deficiency of FcγRIII function in systemic passive anaphylaxis and the reduction of FcγRIII function in a bone marrow-derived mast cell, or the like.