The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2007
Filed:
Jul. 13, 2005
RU Hwu Jih, Hsinchu, TW;
Shwu Chen Tsay, Taipei, TW;
Balaachary Magendran, Hsinchu, TW;
Subhasish K. Chakraborty, Hsinchu, TW;
Asish R. Das, Hsinchu, TW;
Kuen Wang Sheu, Taoyuan, TW;
Chun Mei Shu, Taoyuan, TW;
Chin Kun LU, Taoyuan, TW;
Wei Min Chang, Taoyuan, TW;
Ru Hwu Jih, Hsinchu, TW;
Shwu Chen Tsay, Taipei, TW;
Balaachary Magendran, Hsinchu, TW;
Subhasish K. Chakraborty, Hsinchu, TW;
Asish R. Das, Hsinchu, TW;
Kuen Wang Sheu, Taoyuan, TW;
Chun Mei Shu, Taoyuan, TW;
Chin Kun Lu, Taoyuan, TW;
Wei Min Chang, Taoyuan, TW;
Well-Being Biochemical Corp., Taipei, TW;
Taiwan Biotech Co., Ltd., Tao Yuan Hsien, TW;
Abstract
The present invention discloses a new process for the synthesis of tamsulosin and its aralkylamine derivatives, especially (R)-(−)-5-{2-[2-(2-alkoxyphenoxy) ethylamino]propyl}-2-alkoxybenzenesulfonamides having the following formula 1 (where Rand Rrepresent C-Calkyl groups) and their hydrochloride thereof, and other various pharmaceutical used salts. Tamsulosin hydrochloride (R=Et, R=Me, in its hydrochloride salt form) is an antagonist of α-A adrenoceptors in the prostate. Tamsulosin•HCl occurs as white crystals, which melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether.