The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2007
Filed:
Aug. 20, 2004
David S. Garvey, Dover, MA (US);
L. Gordon Letts, Dover, MA (US);
Manuel Worcel, Boston, MA (US);
Richard A. Earl, Westford, MA (US);
Maiko Ezawa, Acton, MA (US);
Xinqin Fang, Lexington, MA (US);
Subhash P. Khanapure, Clinton, MA (US);
Chia-en Lin, Burlington, MA (US);
Ramani R. Ranatunge, Lexington, MA (US);
Cheri A. Stevenson, Haverhill, MA (US);
David S. Garvey, Dover, MA (US);
L. Gordon Letts, Dover, MA (US);
Manuel Worcel, Boston, MA (US);
Richard A. Earl, Westford, MA (US);
Maiko Ezawa, Acton, MA (US);
Xinqin Fang, Lexington, MA (US);
Subhash P. Khanapure, Clinton, MA (US);
Chia-En Lin, Burlington, MA (US);
Ramani R. Ranatunge, Lexington, MA (US);
Cheri A. Stevenson, Haverhill, MA (US);
NitroMed, Inc., Lexington, MA (US);
Abstract
The invention describes novel nitrosated and/or nitrosylated diuretic compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated diuretic compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one diuretic compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; and (l) treating nephropathy.