The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2007
Filed:
Feb. 20, 2004
Applicants:
Stanislav Radl, Praha 2, CZ;
Kamal Jarrah, Praha 10, CZ;
Inventors:
Stanislav Radl, Praha 2, CZ;
Kamal Jarrah, Praha 10, CZ;
Assignee:
Zentiva, a.s., Praha, CZ;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4015 (2006.01); C07D 207/28 (2006.01);
U.S. Cl.
CPC ...
Abstract
A method of manufacturing glimepiride of formula I wherein trans-4-methylcyclohexylamine pivalate of formula VII is reacted, either directly or after conversion to trans-4-methylcyclohexylamine or to its another salt, with an alkyl [4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1 yl)carbonyl]amino)ethyl)phenyl]-sulfonyl carbamate of general formula IV wherein R is a C1-C5 alkyl, giving glimepiride of formula I, trans-4-Methylcyclohexylamine pivalate of formula VII